FzM1
Product Specifications
CAS Number
1680196-54-6
Target
Wnt/beta-catenin
Related Pathways
Stem Cells, Cytoskeletal Signaling
Purity
0.9989
Bioactivity
FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2) by binding to an allosteric site on intracellular loop 3 (ICL3) of FZD4. This interaction changes the receptor's conformation and inhibits the WNT/β-catenin signaling pathway.
Smiles
Oc1cc(NC(=O)Nc2ccc3ccccc3c2)cc(c1)-c1cccs1
Molecular Formula
C21H16N2O2S
Molecular Weight
360.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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