CLK1/2-IN-3
Product Specifications
CAS Number
1005784-60-0
Target
Serine/threonin kinase, CDK
Related Pathways
Metabolism, Cell Cycle/Checkpoint
Purity
0.9904
Bioactivity
CLK1/2-IN-3 (Cpd-3) is a potent and selective CLK1 and CLK2 inhibitor with antiproliferative activity and inhibits the activities of CLK1, CLK2, SRPK1, SRPK2, and SRPK3.CLK1/2-IN-3 induces nuclear speckle enlargement, which induces S6K pre-mRNA-selective splicing and subsequent inhibition of cell growth of multiple cancer cell types. cancer cell types cell growth.
Smiles
N(C(=O)C1=CC=C(C(CO)(C)C)C=C1)C2=CN3C(=N2)C=CC(=C3)C=4C=NNC4
Molecular Formula
C21H21N5O2
Molecular Weight
375.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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