2'-Fluorothymidine
2'-Fluorothymidine (2'-Fluoro-2'-deoxythymidine), a bioisostere of both thymidine (TdR) and methyluridine, is a putative highly selective substrate for thymidine kinase type 2 (TK2) [1].
Product Specifications
CAS Number
[122799-38-6]
Product Name Alternative
2'-Deoxy-2'-fluoro-5-Methyluridine
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/2-fluorothymidine.html
Concentration
10mM
Purity
99.07
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC[C@@H]1[C@@H](O)[C@@H](F)[C@H](N2C(NC(C(C)=C2)=O)=O)O1
Molecular Formula
C10H13FN2O5
Molecular Weight
260.22
References & Citations
[1]Wiebe LI, et al. Biochemistry and biology of 2'-Fluoro-2'-deoxythymidine (FT), a putative highly selective substrate for thymidine kinase type 2 (TK2) . Curr Radiopharm. 2012 Jan;5 (1) :38-46.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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