2'-Fluorothymidine

2'-Fluorothymidine (2'-Fluoro-2'-deoxythymidine), a bioisostere of both thymidine (TdR) and methyluridine, is a putative highly selective substrate for thymidine kinase type 2 (TK2) [1].

Product Specifications

CAS Number

[122799-38-6]

Product Name Alternative

2'-Deoxy-2'-fluoro-5-Methyluridine

UNSPSC

12352005

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-fluorothymidine.html

Concentration

10mM

Purity

99.07

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC[C@@H]1[C@@H](O)[C@@H](F)[C@H](N2C(NC(C(C)=C2)=O)=O)O1

Molecular Formula

C10H13FN2O5

Molecular Weight

260.22

References & Citations

[1]Wiebe LI, et al. Biochemistry and biology of 2'-Fluoro-2'-deoxythymidine (FT), a putative highly selective substrate for thymidine kinase type 2 (TK2) . Curr Radiopharm. 2012 Jan;5 (1) :38-46.