Ponatinib Hydrochloride
Product Specifications
CAS Number
1114544-31-8
Target
PDGFR, Autophagy, FGFR, VEGFR, Src, Bcr-Abl
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, Autophagy, Cytoskeletal Signaling
Purity
>99.99%
Bioactivity
Ponatinib Hydrochloride (AP-24534 Hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.
Smiles
Cl.CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1
Molecular Formula
C29H28ClF3N6O
Molecular Weight
569.02
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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