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Ponatinib

Product Specifications

CAS Number

943319-70-8

Target

PDGFR, c-Kit, Autophagy, FGFR, VEGFR, Bcr-Abl, Src

Related Pathways

Cytoskeletal Signaling, Autophagy, Angiogenesis, Tyrosine Kinase/Adaptors

Purity

0.9974

Bioactivity

Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor with IC50 values of 0.37 nM (Abl), 1.1 nM (PDGFRα), 1.5 nM (VEGFR2), 2.2 nM (FGFR1), and 5.4 nM (Src) .

Smiles

C(#CC1=CC(C(NC2=CC(C(F)(F)F)=C(CN3CCN(C)CC3)C=C2)=O)=CC=C1C)C=4N5C(=NC4)C=CC=N5

Molecular Formula

C29H27F3N6O

Molecular Weight

532.56

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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