Ponatinib
Product Specifications
CAS Number
943319-70-8
Target
PDGFR, c-Kit, Autophagy, FGFR, VEGFR, Bcr-Abl, Src
Related Pathways
Cytoskeletal Signaling, Autophagy, Angiogenesis, Tyrosine Kinase/Adaptors
Purity
0.9974
Bioactivity
Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor with IC50 values of 0.37 nM (Abl), 1.1 nM (PDGFRα), 1.5 nM (VEGFR2), 2.2 nM (FGFR1), and 5.4 nM (Src) .
Smiles
C(#CC1=CC(C(NC2=CC(C(F)(F)F)=C(CN3CCN(C)CC3)C=C2)=O)=CC=C1C)C=4N5C(=NC4)C=CC=N5
Molecular Formula
C29H27F3N6O
Molecular Weight
532.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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