Ponatinib

Product Specifications

CAS Number

943319-70-8

Target

PDGFR|||c-Kit|||Autophagy|||FGFR|||VEGFR|||Bcr-Abl|||Src

Related Pathways

Cytoskeletal Signaling|||Autophagy|||Angiogenesis|||Tyrosine Kinase/Adaptors

Purity

0.9974

Bioactivity

Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor with IC50 values of 0.37 nM (Abl), 1.1 nM (PDGFR?), 1.5 nM (VEGFR2), 2.2 nM (FGFR1), and 5.4 nM (Src) .

Smiles

C(#CC1=CC(C(NC2=CC(C(F)(F)F)=C(CN3CCN(C)CC3)C=C2)=O)=CC=C1C)C=4N5C(=NC4)C=CC=N5

Molecular Formula

C29H27F3N6O

Molecular Weight

532.56

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

TL712266 1 Kit

Pip4k2a Rat shRNA Plasmid (Locus ID 116723)

Ask

View Details

NBP2-72297PCP 0.1 mL

Mouse Monoclonal DOT1L Antibody (OTI1D8) [PerCP]

Ask

View Details

E60M3747 100 µL

CD74 Rabbit mAb

Ask

View Details

MBS9416948-01 0.1 mL

RASA1 Antibody

Ask

View Details

MBS9416948-02 5x 0.1 mL

RASA1 Antibody

Ask

View Details

RC229690A1V 250 µL

Human Endothelin 1 (EDN1) (NM_001168319) AAV Particle

Ask

View Details