Edoxaban
Product Specifications
CAS Number
480449-70-5
Target
Factor Xa|||Thrombin
Related Pathways
Metabolism|||Proteases/Proteasome
Purity
0.9971
Bioactivity
Edoxaban (Lixiana) (DU-176) is a selective, potent and orally active factor Xa (FXa) inhibitor with K i s of 0.561 nM and 2.98 nM for free FXa and prothrombinase, respectively. Edoxaban is an anticoagulant agent and is able to be used for stroke prevention. Edoxaban is a also weak inhibitor of thrombin and factor IXa? (FIXa), with K i s of 6.00 ?M and 41.7 ?M, respectively, exhibits >10 000-fold selectivity for FXa. Edoxaban has antithrombotic properties and is potential for thromboembolic diseases treatment [1] [2] [3].
Smiles
N(C(=O)C1=NC2=C(S1)CN(C)CC2)[C@H]3[C@@H](NC(C(NC4=CC=C(Cl)C=N4)=O)=O)CC[C@H](C(N(C)C)=O)C3
Molecular Formula
C24H30ClN7O4S
Molecular Weight
548.06
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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