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ABC1183

Product Specifications

CAS Number

1042735-18-1

Target

GSK-3, CDK

Related Pathways

Stem Cells, PI3K/Akt/mTOR signaling, Cell Cycle/Checkpoint

Purity

0.9892

Bioactivity

ABC1183 is a novel diaminothiazole that inhibits GSK3α, GSK3β and CDK9. ABC1183 inhibits the growth of a numerous cancer cell lines by decreasing cell survival by inducing G2/M arrest and through altering GSK3, glycogen synthetase, β-catenin phosphorylation and MCL1 expression, and is orally active.

Smiles

Cc1ccc(Nc2nc(N)c(s2)C(=O)c2ccc(cc2)C#N)cc1

Molecular Formula

C18H14N4OS

Molecular Weight

334.39

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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