ABC1183
Product Specifications
CAS Number
1042735-18-1
Target
GSK-3, CDK
Related Pathways
Stem Cells, PI3K/Akt/mTOR signaling, Cell Cycle/Checkpoint
Purity
0.9892
Bioactivity
ABC1183 is a novel diaminothiazole that inhibits GSK3α, GSK3β and CDK9. ABC1183 inhibits the growth of a numerous cancer cell lines by decreasing cell survival by inducing G2/M arrest and through altering GSK3, glycogen synthetase, β-catenin phosphorylation and MCL1 expression, and is orally active.
Smiles
Cc1ccc(Nc2nc(N)c(s2)C(=O)c2ccc(cc2)C#N)cc1
Molecular Formula
C18H14N4OS
Molecular Weight
334.39
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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