Ethambutol (dihydrochloride)

Ethambutol dihydrochloride is an antimycobacterial compound that prevents cell wall formation by inhibiting arabinosyltransferase activity. Ethambutol dihydrochloride can be used to establish animal models of hyperuricemia and optic neuropathy.

Product Specifications

CAS Number

[1070-11-7]

Product Name Alternative

Emb (dihydrochloride)

UNSPSC

12352211

Hazard Statement

H360

Target

Antibiotic; Bacterial

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Ethambutol-dihydrochloride.html

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

CC[C@H](NCCN[C@@H](CC)CO)CO.Cl.Cl

Molecular Formula

C10H26Cl2N2O2

Molecular Weight

277.23

Precautions

H360

References & Citations

[1]Ethambutol. Tuberculosis (Edinb), 2008. 88 (2) : p. 102-5.|[2]Rastogi N, et al. In vitro activities of fourteen antimicrobial agents against drug susceptible and resistant clinical isolates of Mycobacterium tuberculosis and comparative intracellular activities against the virulent H37Rv strain in human macrophages. Curr Microbiol, 1996. 33 (3) : p. 167-75.|[3]Kaur D, et al. In vitro, ex-vivo and in vivo activities of ethambutol and sparfloxacin alone and in combination against mycobacteria. Int J Antimicrob Agents, 2001. 17 (1) : p. 51-5.|[4]Kang L, et al. Total glucosides of herbaceous peony (Paeonia lactiflora Pall.) flower attenuate adenine- and ethambutol-induced hyperuricaemia in rats. J Ethnopharmacol. 2020 Oct 28;261:113054.|[5]Pham AQ, et al. Pyrazinamide-induced hyperuricemia. P T. 2014 Oct;39 (10) :695-715.|[6]Nusanti S, et al. The Effect of Citicoline on Ethambutol Optic Neuropathy: Histopathology and Immunohistochemistry Analysis of Retina Ganglion Cell Damage Level in Rat Model. J Ocul Pharmacol Ther. 2022 Oct;38 (8) :584-589.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Natural Products

Clinical Information

Launched

Citation 01

ACS Chem Biol. 2022 Jan 21;17 (1) :39-53.|Antimicrob Agents Chemother. 2025 Sep 11:e0079525.|Commun Biol. 2025 Oct 6;8 (1) :1425.|mLife. 2025 Apr 15;4 (2) :155-168.