Y134
Product Specifications
CAS Number
849662-80-2
Target
Estrogen Receptor/ERR
Related Pathways
Endocrinology/Hormones
Purity
0.9998
Bioactivity
Y134 is an estrogen receptor inhibitor that is selective and orally active, exhibiting strong antagonist activity against ERα and Erβ with Ki of 0.09 nM and 11.31 nM, respectively. The selectivity of Y134 for ERα is 121.1 times higher than that for ERβ. Y134 inhibited the proliferation of ER positive human breast cancer cells stimulated by estrogen.
Smiles
C(=O)(C1=C(SC=2C1=CC=C(O)C2)C3=CC=C(O)C=C3)C4=CC=C(C=C4)N5CCN(C(C)C)CC5
Molecular Formula
C28H28N2O3S
Molecular Weight
472.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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