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Y134

Product Specifications

CAS Number

849662-80-2

Target

Estrogen Receptor/ERR

Related Pathways

Endocrinology/Hormones

Purity

0.9998

Bioactivity

Y134 is an estrogen receptor inhibitor that is selective and orally active, exhibiting strong antagonist activity against ERα and Erβ with Ki of 0.09 nM and 11.31 nM, respectively. The selectivity of Y134 for ERα is 121.1 times higher than that for ERβ. Y134 inhibited the proliferation of ER positive human breast cancer cells stimulated by estrogen.

Smiles

C(=O)(C1=C(SC=2C1=CC=C(O)C2)C3=CC=C(O)C=C3)C4=CC=C(C=C4)N5CCN(C(C)C)CC5

Molecular Formula

C28H28N2O3S

Molecular Weight

472.6

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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