PARP14 inhibitor H10
PARP14 inhibitor H10, compound H 10, is a selective inhibitor against PARP14 (IC50=490 nM), over other PARPs (≈24 fold over PARP1) . PARP14 inhibitor H10 induces caspase-3/7-mediated cell apoptosis[1].
Product Specifications
CAS Number
[2084811-68-5]
Product Name Alternative
PQQ (disodium salt); Methoxatin (disodium salt),PQQ; Methoxatin
UNSPSC
12352005
Target
Apoptosis; PARP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parp14-inhibitor-h10.html
Purity
99.46
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=CC(S(=O)(NCCN2N=NC(CCNC(CCC(NC3=CC=CC(C(N)=O)=C3)=O)=O)=C2)=O)=C1
Molecular Formula
C24H27N7O7S
Molecular Weight
557.58
References & Citations
[1]Peng B, et al. Small Molecule Microarray Based Discovery of PARP14 Inhibitors. Angew Chem Int Ed Engl. 2017 Jan 2;56 (1) :248-253.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; PARP14
Available Sizes
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