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TC-N 22A

Product Specifications

CAS Number

1314140-00-5

Target

GluR

Related Pathways

Neuroscience

Purity

0.9995

Bioactivity

TC-N 22A is a strong, selective, oral active mGlu4 forward allosteric regulator (PAM) that can cross the blood-brain barrier. EC50 expression of TC-N 22A in BHK cells expressing human mGlu4 was 9 nM. TC-N 22A showed very low activity against mGlu 1, 2, 3, 5, and 7 receptors in excitation and forward allosteric models (EC50 >10 μM) . TC-N 22A can be used in the study of central nervous system diseases.

Smiles

N(C1=NC=2C=3C(=NNC3)CCCC2S1)C4=CC=CC=N4

Molecular Formula

C14H13N5S

Molecular Weight

283.35

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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