Ralinepag

Ralinepag is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively.

Product Specifications

CAS Number

[1187856-49-0]

Product Name Alternative

APD811

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Ralinepag.html

Purity

99.79

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(O)COC[C@H]1CC[C@H](COC(N(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)=O)CC1

Molecular Formula

C23H26ClNO5

Molecular Weight

431.91

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

References & Citations

[1]Tran TA, et al. Discovery of 2- (((1r,4r) -4- (((4-Chlorophenyl) (phenyl) carbamoyl) oxy) methyl) cyclohexyl) methoxy) acetate (Ralinepag) : An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension. J Med Chem. 2017 Feb 9;60 (3) :913-927.