RS 67333 hydrochloride
Product Specifications
CAS Number
168986-60-5
Target
5-HT Receptor
Related Pathways
GPCR/G Protein|||Neuroscience
Purity
0.9976
Bioactivity
RS 67333 hydrochloride (RO5203648) is a potent, selective partial agonist of the 5-HT4 receptor (5-HT4R) with a pKi value of 8.7 in guinea-pig striatum. It demonstrates lower binding affinities for other receptors, including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1 and D2, and muscarinic M1-M3 receptors. Notably, RS 67333 hydrochloride exhibits neuroprotective properties, rendering it useful in Alzheimer's disease research.
Smiles
Cl.O=C(C=1C=C(Cl)C(N)=CC1OC)CCC2CCN(CCCC)CC2
Molecular Formula
C19H30Cl2N2O2
Molecular Weight
389.36
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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