Human CellExp™ SARS-CoV-2 S1 Protein (D614G), Recombinant

SARS-CoV-2, the causative virus of COVID-19, uses the viral Spike (S) protein for host cell attachment and entry. The virus uses multiple factors including the human protease Furin, Angiotensin converting enzyme 2 (ACE2), Neuropilin-1 (NRP1) and the transmembrane protease serine 2 (TMPRSS2) for receptor interactions. The S protein has two domains S1 and S2, where S1 facilitates initial binding to the receptor and the S2 domain drives the membrane fusion and eventual entry of the virus. The S glycoprotein serves as an important target for monoclonal antibodies, entry inhibitors, and vaccines. Within the S1 protein, the conserved receptor-binding domain (RBD) binds with a high affinity for ACE2. Recently, a new strain of SARS-CoV-2 has been discovered with a mutation in the S1 protein (amino acid D614 to G614) outside the RBD. Early studies provide evidence that D614G SARS-CoV-2 virus strain is likely to be more infectious and is present in the majority of current infections globally.