Polyinosinic-polycytidylic acid
Product Specifications
CAS Number
24939-03-5
Target
Bcl-2 Family, Apoptosis, HSP, Serine/threonin kinase, TLR, Interleukin
Related Pathways
Cytoskeletal Signaling, Cell Cycle/Checkpoint, Metabolism, Immunology/Inflammation, Apoptosis
Purity
0.9
Bioactivity
Polyinosinic-polycytidylic acid (Poly (I:C) ) is a synthetic double-stranded RNA (dsRNA) analog and an agonist of TLR3 as well as retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) . It can induce innate immune responses in mammals and serve as a vaccine adjuvant to enhance both innate and adaptive immunity, while modulating the tumor microenvironment and directly inducing apoptosis in cancer cells. Poly (I:C) is commonly used to establish acute respiratory distress syndrome (ARDS) animal models for studying immune responses and disease mechanisms.
Smiles
Nc1ccn([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)n1.O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c1nc[nH]c2=O
Molecular Formula
(C10H13N4O8P) x. (C9H14N3O8P) x
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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