PB28 dihydrochloride
Product Specifications
CAS Number
172907-03-8
Target
Sigma receptor, SARS-CoV, Apoptosis
Related Pathways
Apoptosis, Microbiology/Virology, GPCR/G Protein
Purity
0.9997
Bioactivity
PB28 dihydrochloride is a selective and potent sigma 2 (σ2) receptor agonist and σ1 receptor antagonist with anti-SARS-CoV-2 activity and anti-tumor activity, which inhibits cell proliferation and invasion and suppresses SKF by modulating the PI3K-AKT-mTOR signaling pathway in renal cancer. It inhibits cell proliferation and invasion by regulating the PI3K-AKT-mTOR signaling pathway in renal cancer, inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells, and induces non-caspase-dependent apoptosis.
Smiles
COC1=CC=CC2=C1CCCC2CCCN3CCN(C4CCCCC4)CC3.Cl.Cl
Molecular Formula
C24H40Cl2N2O
Molecular Weight
443.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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