CHIR-99021
Product Specifications
CAS Number
252917-06-9
Target
Wnt/beta-catenin, Autophagy, GSK-3
Related Pathways
Cytoskeletal Signaling, PI3K/Akt/mTOR signaling, Stem Cells, Autophagy
Purity
0.9929
Bioactivity
CHIR-99021 (CT99021) is an activator of the Wnt/β-catenin signaling pathway and a GSK-3α/β inhibitor (IC50=10/6.7 nM) with selective and oral activity.CHIR-99021 induces cellular autophagy, which enhances self-renewal in mouse and human embryonic stem cells.
Smiles
Cc1c[nH]c(n1)-c1cnc(NCCNc2ccc(cn2)C#N)nc1-c1ccc(Cl)cc1Cl
Molecular Formula
C22H18Cl2N8
Molecular Weight
465.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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