Nafamostat
Product Specifications
CAS Number
81525-10-2
Target
Serine Protease, SARS-CoV, Apoptosis, NF-κB, Anti-infection, TNF
Related Pathways
Microbiology/Virology, Apoptosis, Proteases/Proteasome, NF-κB
Bioactivity
Nafamostat is a synthetic serine protease inhibitor and an anticoagulant used in haemodialysis. It induces apoptosis by upregulating TNFR1 expression, inhibits NF-κB activity by blocking IκBα phosphorylation, and can also inhibit SARS-CoV-2 and COVID-19.
Smiles
O=C(OC=1C=CC2=CC(=CC=C2C1)C(=N)N)C3=CC=C(C=C3)NC(=N)N
Molecular Formula
C19H17N5O2
Molecular Weight
347.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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