LE135
Product Specifications
CAS Number
155877-83-1
Target
Retinoid Receptor, TRP/TRPV Channel
Related Pathways
Membrane transporter/Ion channel, Metabolism
Purity
0.9833
Bioactivity
LE135 is a potent RAR antagonist that binds selectively to RARα (Ki of 1.4 μM) and RARβ (Ki of 220 nM), showing higher affinity for RARβ. It is highly selective over RARγ, RXRα, RXRβ, and RXRγ. LE135 also acts as a potent TRPV1 and TRPA1 receptor activator with EC50s of 2.5 μM and 20 μM, respectively.
Smiles
CN1c2cc3c(cc2N=C(c2ccc(cc2)C(O)=O)c2ccccc12)C(C)(C)CCC3(C)C
Molecular Formula
C29H30N2O2
Molecular Weight
438.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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