PX-12
Product Specifications
CAS Number
141400-58-0
Target
Others, Apoptosis, Thioredoxin
Related Pathways
Metabolism, Others, Apoptosis
Purity
0.996
Bioactivity
PX-12 (PX12) (1-methylpropyl 2-imidazolyl disulfide) is a small-molecule inhibitor of Trx-1 (thioredoxin-1), stimulates apoptosis, down-regulates HIF-1α and vascular endothelial growth factor (VEGF) and inhibits tumor growth in animal models. Since high levels of Trx-1 have been associated with colorectal, gastric and lung cancers, PX-12 is indicated as a potential cancer treatment in combination with chemotherapy for patients with advanced metastatic cancer. Initial trials correlated doses of Px-12 with increased patient survival.
Smiles
CCC(C)SSc1ncc[nH]1
Molecular Formula
C7H12N2S2
Molecular Weight
188.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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