GW 583340 dihydrochloride
Product Specifications
CAS Number
1173023-85-2
Target
EGFR
Related Pathways
JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors
Purity
0.988
Bioactivity
GW 583340 dihydrochloride is a potent and orally available dual EGFR/ErbB2 (epidermal growth factor receptor/tyrosine kinase) inhibitor and is capable of reversing ABCG2- and ABCB1-mediated resistance.GW 583340 dihydrochloride selectively inhibits the growth of human tumor cells overexpressing EGFR and ErbB2, selectively inhibits the growth of human tumor cells overexpressing EGFR and ErbB2, and inhibits 80% of tumor growth in a mouse xenograft model, with potential anticancer activity.
Smiles
O=S(C)(CCNCC1=NC(C2=CC3=C(NC4=CC=C(C(Cl)=C4)OCC5=CC(F)=CC=C5)N=CN=C3C=C2)=CS1)=O.Cl.Cl
Molecular Formula
C28H27Cl3FN5O3S2
Molecular Weight
671.03
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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