KH-CB19
KH-CB19 is a potent CLK (cdc2-like kinase) inhibitor (CLK1 IC50=19.7 nM; CLK3 IC50=530 nM) . KH-CB19 shows antiviral activity and inhibits influenza virus replication (IC50=13.6 μM) [1][2].
Product Specifications
CAS Number
1354037-26-5
UNSPSC
12352005
Hazard Statement
H302
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/KH-CB19.html
Purity
99.31
Solubility
DMSO : ≥ 50 mg/mL
Smiles
CCOC(C1=C(C2=C(C(Cl)=C(C=C2)Cl)N1C)/C(C#N)=C\N)=O
Molecular Formula
C15H13Cl2N3O2
Molecular Weight
338.19
Precautions
H302
References & Citations
[1]Fedorov O, et al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011 Jan 28;18 (1) :67-76.|[2]Artarini A, et al. Regulation of influenza A virus mRNA splicing by CLK1. Antiviral Res. 2019 Aug;168:187-196.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CLK
Available Sizes
Frequently Asked Questions
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