KH-CB19

KH-CB19 is a potent CLK (cdc2-like kinase) inhibitor (CLK1 IC50=19.7 nM; CLK3 IC50=530 nM) . KH-CB19 shows antiviral activity and inhibits influenza virus replication (IC50=13.6 μM) [1][2].

Product Specifications

CAS Number

[1354037-26-5]

UNSPSC

12352005

Hazard Statement

H302

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/KH-CB19.html

Purity

99.31

Solubility

DMSO : ≥ 50 mg/mL

Smiles

CCOC(C1=C(C2=C(C(Cl)=C(C=C2)Cl)N1C)/C(C#N)=C\N)=O

Molecular Formula

C15H13Cl2N3O2

Molecular Weight

338.19

Precautions

H302

References & Citations

[1]Fedorov O, et al. Specific CLK inhibitors from a novel chemotype for regulation of alternative splicing. Chem Biol. 2011 Jan 28;18 (1) :67-76.|[2]Artarini A, et al. Regulation of influenza A virus mRNA splicing by CLK1. Antiviral Res. 2019 Aug;168:187-196.