EC 144
Product Specifications
CAS Number
911397-80-3
Target
HSP
Related Pathways
Metabolism, Cytoskeletal Signaling
Bioactivity
EC 144, a second-generation selective inhibitor of Hsp90 (heat shock protein 90), inhibits tumor growth with an IC50= 1.1 nM for Hsp90α and an EC50 = 14 nM for degradation of Her-2 in MCF-7 cells.
Smiles
ClC1=NC(=NC2=C1C(C#CCC(O)(C)C)=CN2CC3=NC=C(C(OC)=C3C)C)N
Molecular Formula
C21H24ClN5O2
Molecular Weight
413.9
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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