Aristolochic acid B

Aristolochic acid B (Aristolochic Acid II) is an orally active major component of aristolochic acid (AA) . Aristolochic acid B can be isolated from plants of the genus Aristolochica. Aristolochic acid B forms DNA adducts. Aristolochic acid B is mutagenic. Aristolochic acid B exhibits a greater carcinogenic risk in vivo than Aristolochic acid I (HY-N0510) [1][2][3].

Product Specifications

CAS Number

[475-80-9]

Product Name Alternative

Aristolochic acid II

UNSPSC

12352005

Hazard Statement

H301+H311+H331, H341, H351

Target

DNA Alkylator/Crosslinker

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/aristolochic-acid-b.html

Purity

99.92

Solubility

DMSO : 11.11 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C2C([N+]([O-])=O)=CC3=CC=CC=C3C2=C(OCO4)C4=C1)O

Molecular Formula

C16H9NO6

Molecular Weight

311.25

Precautions

H301+H311+H331, H341, H351

References & Citations

[1]Xing G, et al. Comparison of the mutagenicity of aristolochic acid I and aristolochic acid II in the gpt delta transgenic mouse kidney. Mutat Res. 2012 Mar 18;743 (1-2) :52-8.|[2]Yeh YH, et al. Short-term toxicity of aristolochic acid, aristolochic acid-I and aristolochic acid-II in rats. Food Chem Toxicol. 2008 Mar;46 (3) :1157-63. |[3]Schmeiser HH, et al. DNA adduct formation of aristolochic acid I and II in vitro and in vivo. Carcinogenesis. 1988 Feb;9 (2) :297-303.