Laduviglusib trihydrochloride
Product Specifications
CAS Number
1782235-14-6
Target
Autophagy, GSK-3, Wnt/beta-catenin
Related Pathways
Cytoskeletal Signaling, Stem Cells, PI3K/Akt/mTOR signaling, Autophagy
Purity
0.9934
Bioactivity
Laduviglusib trihydrochloride (CT99021 trihydrochloride) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor with IC50s of 10 nM and 6.7 nM for GSK-3α and GSK-3β. Laduviglusib trihydrochloride inhibits human GSK-3β with a Ki of 9.8 nM. Laduviglusib trihydrochloride is an activator of Wnt/β-catenin signaling. Laduviglusib trihydrochloride induces autophagy.
Smiles
Cl.Cl.Cl.Cc1cnc([nH]1)-c1cnc(NCCNc2ccc(cn2)C#N)nc1-c1ccc(Cl)cc1Cl
Molecular Formula
C22H20Cl5N8
Molecular Weight
573.71
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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