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6-Chloromelatonin

Product Specifications

CAS Number

63762-74-3

Target

Melatonin Receptor|||Dopamine Receptor

Related Pathways

Neuroscience|||GPCR/G Protein

Purity

0.9936

Bioactivity

6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for presynaptic melatonin receptor sites in the rabbit retina, inhibiting the calcium-dependent release of [3H]dopamine with higher metabolic stability than melatonin. Chloromelatonin competitively binds to [3H]melatonin at MT2 receptors (pKi=9.77) and may be used to study insomnia and sleep disorders associated with depression.

Smiles

C(CNC(C)=O)C=1C=2C(=CC(Cl)=C(OC)C2)NC1

Molecular Formula

C13H15ClN2O2

Molecular Weight

266.72

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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