6-Chloromelatonin
Product Specifications
CAS Number
63762-74-3
Target
Melatonin Receptor|||Dopamine Receptor
Related Pathways
Neuroscience|||GPCR/G Protein
Purity
0.9936
Bioactivity
6-Chloromelatonin is a potent melatonin receptor agonist, a 5-methoxyindole compound that competes for presynaptic melatonin receptor sites in the rabbit retina, inhibiting the calcium-dependent release of [3H]dopamine with higher metabolic stability than melatonin. Chloromelatonin competitively binds to [3H]melatonin at MT2 receptors (pKi=9.77) and may be used to study insomnia and sleep disorders associated with depression.
Smiles
C(CNC(C)=O)C=1C=2C(=CC(Cl)=C(OC)C2)NC1
Molecular Formula
C13H15ClN2O2
Molecular Weight
266.72
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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