(±) -AMG 487

Product Specifications

Target

CXCR|||Others

Related Pathways

Autophagy|||Immunology/Inflammation|||GPCR/G Protein|||Others

Bioactivity

AMG 487 is an effective and selective antagonist of chemokine receptor 3. AMG 487 inhibited CXCR3-mediated cell migration induced by three CXCR3 chemokines, IP-10, ITAC and MIG (IC50: 8, 15 and 36 nM, respectively) .

Smiles

CCOC1=CC=C(N2C(C(N(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)CC4=CN=CC=C4)C)=NC5=C(C2=O)C=CC=N5)C=C1

Molecular Formula

C32H28F3N5O4

Molecular Weight

603.59

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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