Isoforskolin
Product Specifications
UNSPSC Description
Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, IL-6 and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis[1].
Target Antigen
Interleukin Related; TNF Receptor
Type
Natural Products
Related Pathways
Apoptosis;Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/isoforskolin.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@@]3([C@@]([C@@H](O)[C@@H](OC(C)=O)[C@@]1([H])C(C)(CC[C@@H]2O)C)(O[C@](C=C)(C)CC3=O)C)O
Molecular Weight
410.50
References & Citations
[1]Zhao H, et al. Isoforskolin downregulates proinflammatory responses induced by <i>Borrelia burgdorferi</i> basic membrane protein A.Exp Ther Med. 2017 Dec;14(6):5974-5980.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N6927/Isoforskolin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N6927/Isoforskolin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
64657-21-2
Available Sizes
Curated Selection
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