PF-6274484
Product Specifications
CAS Number
1035638-91-5
Target
EGFR
Related Pathways
JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors
Purity
0.9912
Bioactivity
PF-6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively.
Smiles
COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C
Molecular Formula
C18H14ClFN4O2
Molecular Weight
372.78
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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