What is the catalog number for PF-6274484?

The catalog number for PF-6274484 is T22396.

What sizes are available for PF-6274484?

PF-6274484 is available in the following size(s): 2 mg, 5 mg, 1 mL - 10 mM (in DMSO), 10 mg, 25 mg, 50 mg, 100 mg, 500 mg.

How many pack sizes does PF-6274484 come in?

PF-6274484 is available in 8 different pack sizes.

Is PF-6274484 in stock?

PF-6274484 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures PF-6274484?

PF-6274484 is manufactured by Molfinity.

What is the estimated delivery time for PF-6274484?

Estimated delivery time for PF-6274484 is approximately 10 business day(s), depending on your location.

PF-6274484

Product Specifications

CAS Number

1035638-91-5

Target

EGFR

Related Pathways

JAK/STAT signaling, Angiogenesis, Tyrosine Kinase/Adaptors

Purity

0.9912

Bioactivity

PF-6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively.

Smiles

COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C

Molecular Formula

C18H14ClFN4O2

Molecular Weight

372.78

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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