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GSK-114

Product Specifications

CAS Number

1301761-96-5

Target

MAPK, Others

Related Pathways

Others, MAPK

Purity

0.9966

Bioactivity

GSK-114 is a selective inhibitor of TNNI3 interacting kinase (TNNI3K) with an IC50 of 25 nM, 40-fold significant bias for TNNI3K compared to B-Raf with an IC50 of 1000 nM, so GSK-114 has excellent Broad-spectrum kinase selectivity and sufficient oral exposure enable use in cellular and in vivo studies.

Smiles

CNS(=O)(=O)c1ccc(N(C)C)c(Nc2ncnc3cc(OC)c(OC)cc23)c1

Molecular Formula

C19H23N5O4S

Molecular Weight

417.48

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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