GNE-490
Product Specifications
CAS Number
1033739-92-2
Target
PI3K, mTOR
Related Pathways
PI3K/Akt/mTOR signaling
Purity
0.9977
Bioactivity
GNE-490 is an effective inhibitor of pan-PI3K with IC50s of 3.5 nM, 25 nM, 5.2 nM, 15 nM for PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ, respectively. GNE-490 has >200 fold selectivity for mTOR (IC50 = 750 nM) .
Smiles
Cc1nc(N)ncc1-c1nc(N2CCOCC2)c2sc(cc2n1)C(C)(C)O
Molecular Formula
C18H22N6O2S
Molecular Weight
386.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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