Ensartinib hydrochloride
Product Specifications
CAS Number
2137030-98-7
Target
ALK, c-Met/HGFR, Trk receptor
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors
Purity
0.9929
Bioactivity
Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations. It potently inhibits both wild-type ALK and ALK variants (C1156Y, F1174, G1202R, L1196M, S1206R, and T1151 mutants) with in vitro IC50s of <4 nM.
Smiles
Cl.Cl.C[C@@H](Oc1cc(nnc1N)C(=O)Nc1ccc(cc1)C(=O)N1C[C@H](C)N[C@H](C)C1)c1c(Cl)ccc(F)c1Cl
Molecular Formula
C26H29Cl4FN6O3
Molecular Weight
634.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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