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Ensartinib hydrochloride

Product Specifications

CAS Number

2137030-98-7

Target

ALK, c-Met/HGFR, Trk receptor

Related Pathways

Angiogenesis, Tyrosine Kinase/Adaptors

Purity

0.9929

Bioactivity

Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations. It potently inhibits both wild-type ALK and ALK variants (C1156Y, F1174, G1202R, L1196M, S1206R, and T1151 mutants) with in vitro IC50s of <4 nM.

Smiles

Cl.Cl.C[C@@H](Oc1cc(nnc1N)C(=O)Nc1ccc(cc1)C(=O)N1C[C@H](C)N[C@H](C)C1)c1c(Cl)ccc(F)c1Cl

Molecular Formula

C26H29Cl4FN6O3

Molecular Weight

634.36

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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