Lifirafenib
Product Specifications
CAS Number
1446090-79-4
Target
EGFR, Raf
Related Pathways
MAPK, Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors
Purity
0.9825
Bioactivity
Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant respectively.
Smiles
[H][C@]12Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@]1([H])[C@@H]2c1nc2ccc(cc2[nH]1)C(F)(F)F
Molecular Formula
C25H17F3N4O3
Molecular Weight
478.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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