Miransertib hydrochloride
Product Specifications
CAS Number
1313883-00-9
Target
Akt, Parasite
Related Pathways
Cytoskeletal Signaling, Microbiology/Virology, PI3K/Akt/mTOR signaling
Purity
0.9981
Bioactivity
Miransertib hydrochloride (ARQ-092 hydrochloride) is a potent, orally bioavailable, selective, and allosteric inhibitor of Akt with an IC50 of 2.7 nM, 14 nM, and 8.1 nM against Akt1, Akt2, and Akt3, respectively. It also shows significant potency against the AKT1-E17K mutant protein and holds promise for research on PI3K/AKT-driven tumors and Proteus syndrome. Additionally, Miransertib hydrochloride exhibits efficacy against Leishmania [1, 2].
Smiles
Cl.Nc1ncccc1-c1nc2ccc(nc2n1-c1ccc(cc1)C1(N)CCC1)-c1ccccc1
Molecular Formula
C27H25ClN6
Molecular Weight
468.98
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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