AMI-1 free acid
Product Specifications
CAS Number
134-47-4
Target
Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic
Purity
0.978
Bioactivity
AMI-1 free acid is a potent, cell-permeable, and reversible inhibitor of protein arginine N-methyltransferases (PRMTs), with inhibitory concentration 50 (IC50) values of 8.8 μM for human PRMT1 and 3.0 μM for yeast-Hmt1p. It achieves its PRMTs inhibitory activity by obstructing peptide-substrate binding [1].
Smiles
O=C(NC=1C=CC2=C(O)C=C(C=C2C1)S(=O)(=O)O)NC=3C=CC4=C(O)C=C(C=C4C3)S(=O)(=O)O
Molecular Formula
C21H16N2O9S2
Molecular Weight
504.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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