3PO
Product Specifications
CAS Number
18550-98-6
Target
Glucokinase, Autophagy
Related Pathways
Autophagy, Metabolism
Purity
0.9967
Bioactivity
3PO is a small-molecule inhibitor of PFKFB3 (IC50: 22.9 μM), inhibiting the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines (IC50: 1.4-24 μM) . It suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.
Smiles
O=C(\C=C\c1cccnc1)c1ccncc1
Molecular Formula
C13H10N2O
Molecular Weight
210.23
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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