YS-121

Product Specifications

CAS Number

916482-17-2

Target

Others, PGE Synthase, Lipoxygenase

Related Pathways

Metabolism, Immunology/Inflammation, Others

Bioactivity

YS121 is a dual inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1; IC50=3.4 μM) and 5-lipoxygenase (5-LOX; IC50=6.5 μM) . YS121 dose-dependently reduces the production of PGE2 with EC50=12 μM in IL-1β-stimulated A549 cells [1].

Smiles

N(C1=NC(SC(CCCCCC)C(O)=O)=NC(Cl)=C1)C2=C(C)C(C)=CC=C2

Molecular Formula

C20H26ClN3O2S

Molecular Weight

407.96

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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