MEG hemisulfate
Product Specifications
CAS Number
3979-00-8
Target
NOS, NO Synthase
Related Pathways
Immunology/Inflammation
Purity
0.9981
Bioactivity
MEG hemisulfate (Mercaptoethylguanidine hemisulfate) acts as a highly potent and selective suppressor of inducible NO synthase (iNOS), demonstrating EC50 values of 11.5 μM for iNOS, 110 μM for ecNOS, and 60 μM for bNOS in tissue homogenates. It is notably effective as a peroxynitrite scavenger and blocks peroxynitrite-triggered oxidative mechanisms. Furthermore, this compound offers protective benefits across various experimental inflammation prototypes, such as ischemia/reperfusion injury, hemorrhagic shock, periodontitis, inflammatory bowel disease, and both endotoxic and septic shock.
Smiles
O=S(O)(O)=O.N=C(NCCS)N.N=C(NCCS)N
Molecular Formula
C6H20N6O4S3
Molecular Weight
336.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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