MEG hemisulfate

Product Specifications

CAS Number

3979-00-8

Target

NOS|||NO Synthase

Related Pathways

Immunology/Inflammation

Purity

0.9981

Bioactivity

MEG hemisulfate (Mercaptoethylguanidine hemisulfate) acts as a highly potent and selective suppressor of inducible NO synthase (iNOS), demonstrating EC50 values of 11.5 ?M for iNOS, 110 ?M for ecNOS, and 60 ?M for bNOS in tissue homogenates. It is notably effective as a peroxynitrite scavenger and blocks peroxynitrite-triggered oxidative mechanisms. Furthermore, this compound offers protective benefits across various experimental inflammation prototypes, such as ischemia/reperfusion injury, hemorrhagic shock, periodontitis, inflammatory bowel disease, and both endotoxic and septic shock.

Smiles

O=S(O)(O)=O.N=C(NCCS)N.N=C(NCCS)N

Molecular Formula

C6H20N6O4S3

Molecular Weight

336.44

Shipping Conditions

Cool pack

Storage Temperature

-20°C