CRT5
Product Specifications
CAS Number
1034297-58-9
Target
Others, Serine/threonin kinase
Related Pathways
Metabolism, Cell Cycle/Checkpoint, Others
Bioactivity
CRT5, a pyrazine benzamide, is a potent and selective PKD inhibitor. It inhibits VEGF-induced phosphorylation of three PKD substrates (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively), histone deacetylase 5, CREB (cAMP-response-element-binding protein), and HSP27 (heat-shock protein 27) at Ser82. Additionally, CRT5 decreases VEGF-induced endothelial migration, proliferation, and tubulogenesis[1].
Smiles
NC1=C(C=C(C=N1)C2=CC(C(NCCN(C)C)=O)=CC=C2)C3=CC4=C(C=C3)C=C(OCC)C=C4
Molecular Formula
C28H30N4O2
Molecular Weight
454.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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