SEW2871
Product Specifications
CAS Number
256414-75-2
Target
LPL Receptor, S1P Receptor, ERK, Akt
Related Pathways
MAPK, GPCR/G Protein, PI3K/Akt/mTOR signaling, Cytoskeletal Signaling
Purity
0.9996
Bioactivity
SEW 2871 is an orally available, highly selective S1P1 agonist with an EC50 of 13.8 nM.It reduces the number of lymphocytes in the blood and is used in studies related to diabetes, Alzheimer's disease, liver fibrosis, and inflammation. It activates ERK, Akt and Rac signaling pathways and induces S1P1 internalization and recycling.
Smiles
FC(F)(F)c1sc(cc1-c1ccccc1)-c1nc(no1)-c1cccc(c1)C(F)(F)F
Molecular Formula
C20H10F6N2OS
Molecular Weight
440.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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