AACOCF3
Product Specifications
CAS Number
149301-79-1
Target
Phospholipase
Related Pathways
Metabolism
Purity
0.99
Bioactivity
AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid and a potent, selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2) . By blocking the production of arachidonate and 12-hydroxyeicosatetraenoic acid in calcium ionophore-challenged platelets, AACOCF3 hinders their synthesis. Additionally, AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets, making it promising for cardiovascular disease research.
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C(\CCCC(C(F)(F)F)=O)=C\C/C=C\C/C=C\C/C=C\CCCCC
Molecular Formula
C21H31F3O
Molecular Weight
356.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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